Need a little skin pick-me-up? Restylane® Refyne is a clear gel formulation of hyaluronic acid combined with the innovative technology, XpresHAn™, to improve the appearance of fine to moderate lines in the face. Our HA and collagen levels decrease over time, which leads to loose skin and wrinkles. This Galderma product targets the areas around the mouth, including marionette lines and nasolabial folds, to restore lost volume and result in refreshed, natural-looking facial expressions. This cosmetic filler is designed to plump the skin beneath the lines and wrinkles to smooth them out and make them less noticeable, leading to a natural-looking, youthful appearance. Results last up to 1 year.